VDAC2 Mediates the Apoptosis of Cashmere Goat Hair Follicle Stem Cells Through the P53 Signaling Pathway

The study explores the role of VDAC2 in the apoptosis of secondary hair follicle stem cells (SHFSCs) in cashmere goats, focusing on the P53 signaling pathway. Overexpression of VDAC2 was found to promote apoptosis, while its knockdown reduced it, implicating VDAC2 as a key mediator in this process. The research identified key genes such as Bax, P53, Casp3, and Bcl2 as being regulated by VDAC2. The use of a P53 inhibitor, Pifithrin-μ (PFT), was shown to partially alleviate apoptosis induced by VDAC2 overexpression, suggesting potential therapeutic interventions. However, the study's small sample size is noted as a limitation, indicating the need for further research.