TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice

    September 2018 in “Biomedical dermatology
    Youngkeun Choi, Soo Young Choi, Hyonmin Kim, Jeongmin Kim, Mun Sang Ki, In‐Sook An, Jae Yun Jung
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    TLDR A peptide called DPS-1 helps human scalp cells grow and stimulates hair growth in mice.
    In the 2018 study, researchers found that a TGFβ mimetic peptide, DPS-1, promoted the proliferation of human dermal papilla cells in 3D culture and stimulated hair growth in C57BL/6 mice. DPS-1 was shown to increase the expression of hair growth-related genes and activate the WNT/β-catenin signaling pathway. Topical application of DPS-1 on mice resulted in increased hair follicle size and depth compared to controls. The findings suggest DPS-1 as a potential treatment for hair loss, although the number of mice used was not specified. The evidence was based on three independent experiments.
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