Synchronous Fluorescence as a Green and Selective Method for the Simultaneous Determination of Finasteride and Tadalafil in Dosage Form and Spiked Human Plasma

    May 2023 in “ Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ”
    Hesham Salem, Amany Abdelaziz, Mariam Galal … Deena A. Moukhtar
    Studysummary This study developed a synchronized fluorescence spectroscopic approach to quantify finasteride and tadalafil in various forms, achieving high accuracy with %recoveries of about 99.62% and 100.19% respectively, and demonstrated superior environmental friendliness compared to previous methods.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on linkinghub.elsevier.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Simultaneous Spectrophotometric Determination of Finasteride and Tadalafil in Recently FDA Approved Entadfi Capsules BMC chemistry · 2022
    2. Selective and Rapid Determination of Tadalafil and Finasteride Using Solid Phase Extraction by High Performance Liquid Chromatography and Tandem Mass Spectrometry Journal of Pharmaceutical and Biomedical Analysis · 2018
    3. Evidence for the Efficacy and Safety of Tadalafil and Finasteride in Combination for the Treatment of Lower Urinary Tract Symptoms and Erectile Dysfunction in Men with Benign Prostatic Hyperplasia Therapeutic advances in urology · 2016
    4. Spectrofluorimetric Study of Finasteride and Bovine Serum Albumin Interaction and Its Application for Quantitative Determination of Finasteride in Tablet Dosage Form Analytical Methods · 2015
    5. Rapid Determination of Finasteride in Human Plasma by UPLC-MS/MS and Its Application to Clinical Pharmacokinetic Study Journal of Chromatography B · 2010
    6. Voltammetric Reduction of Finasteride at Mercury Electrode and Its Determination in Tablets Talanta · 2008
    7. A New Spectrophotometric Method for the Determination of Finasteride in Tablets Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 2006
    8. Development and Validation of a New Gas Flame Ionization Detector Method for the Determination of Finasteride in Tablets Analytical Biochemistry · 2006
    9. Polarographic Behavior and Determination of Finasteride Farmaco · 2003
    10. LC Determination of Finasteride and Its Application to Storage Stability Studies Journal of Pharmaceutical and Biomedical Analysis · 2001
    11. Determination of Finasteride in Human Plasma by Liquid-Liquid Extraction and High-Performance Liquid Chromatography Journal of Chromatography B: Biomedical Sciences and Applications · 2000
    12. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    13. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994

    Related research 2

    1. Simultaneous Spectrophotometric Determination of Finasteride and Tadalafil in Recently FDA Approved Entadfi Capsules BMC chemistry · 2022
    2. Safety and Efficacy of Advanced and Targeted Acid α-Glucosidase (AT-GAA) (ATB200/AT2221) in ERT-Switch Nonambulatory Patients with Pompe Disease: Preliminary Results from the ATB200-02 Trial Molecular genetics and metabolism · 2019