Statins for Women with Polycystic Ovary Syndrome Not Actively Trying to Conceive

    July 2023 in “ Cochrane Database of Systematic Reviews ”
    Ting Xiong, Éloïse Fraison, Eleni Kolibianaki, Michael Costello, Christos Venetis, Elena Kostova
    TLDR The effectiveness of statins for women with PCOS is unclear.
    The review on the use of statins for women with polycystic ovary syndrome (PCOS) not actively trying to conceive found very low certainty in the evidence for all main outcomes. It remains uncertain whether statins alone or in combination with metformin improve menstrual regularity compared to placebo or metformin alone. Additionally, the impact of statins on hirsutism, acne severity, or testosterone levels is unclear. No significant differences in adverse events were reported between the groups in the trials. Overall, the limited evidence does not provide a clear conclusion on the effectiveness of statins for these outcomes in women with PCOS.
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