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GlossarySimvastatin (Zocor)

medication that lowers cholesterol by inhibiting liver enzyme production

Simvastatin, also known by the brand name Zocor, is a medication used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins, which work by inhibiting an enzyme involved in the production of cholesterol in the liver. This helps reduce the risk of cardiovascular diseases such as heart attacks and strokes.

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research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

68 citations, January 2022 in “International Journal of Molecular Sciences”

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

46 citations, January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

research Skin-Specific Regulation of SREBP Processing and Lipid Biosynthesis by Glycerol Kinase 5

18 citations, June 2017 in “Proceedings of the National Academy of Sciences of the United States of America”

A gene called Gk5 controls lipid production in the skin and affects hair growth.

research Simvastatin/Ezetimibe Therapy for Recalcitrant Alopecia Areata: An Open Prospective Study of 14 Patients

13 citations, January 2017 in “Annals of dermatology/Annals of Dermatology”

Simvastatin/ezetimibe may help some patients with severe alopecia areata regrow hair.

The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women with Non-Classic Congenital Adrenal Hyperplasia

research The Effect of Simvastatin on Plasma Steroid Hormone Levels in Metformin-Treated Women with Non-Classic Congenital Adrenal Hyperplasia

7 citations, January 2016 in “Experimental and Clinical Endocrinology & Diabetes”

Simvastatin may help manage symptoms in women with non-classic congenital adrenal hyperplasia by lowering cholesterol and certain hormone levels.

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