Formulation, Optimization and In Vivo Evaluation of Smartlipid Nanocarrier Gel of Berberine in Testosterone-Induced Androgenetic Alopecia

    July 2026 in “ Pharmacological Research - Modern Chinese Medicine ”
    Sagarika Majhi, Iti Chauhan, Madhu Verma, Lubhan Singh
    Studysummary In this study, researchers developed and optimized a smartlipid nanocarrier gel formulation of berberine that significantly reduced hair loss and promoted faster hair regrowth in a testosterone-induced hair loss model, showing potential as an effective treatment for androgenetic alopecia.
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    Research cited in this study 12

    1. Shen-Ying-Yang-Zhen Formula Promotes Angiogenesis Around Hair Follicles, Alleviates Oxidative Stress, and Inhibits Hair Follicle Apoptosis Through the VEGF/Akt/Caspase-9 Signaling Axis Phytomedicine · 2025
    2. Berberine Promotes Hair Growth by Targeting Axin2 and Activating Wnt/β-Catenin Pathway Phytomedicine · 2025
    3. Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives Plants · 2023
    4. The Medicinal Activity of Lyophilized Aqueous Seed Extract of Lepidium Sativum L. in an Androgenic Alopecia Model Scientific Reports · 2023
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    10. 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment Journal of Ethnopharmacology · 2011
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