Skin Organogenesis and Dysmorphogenetic Factors in Skin Diseases: A Review

December 2018 in “ Sovremennye tehnologii v medicine ”

N. V. Yaglova, С. С. Обернихин, Д. А. Цомартова, Mihaylova-Goleminova Ivanova, Н. Л. Карташкина, Elizaveta V. Chereshneva

Wnt signaling hair follicle morphogenesis cell proliferation cell differentiation epigenetic regulation prenatal disorders alopecia epidermal histogenesis dermal histogenesis

Studysummary This study found that activation of a mother's immune system during early pregnancy in mice led to transient alopecia in their offspring, highlighting a link between epidermal and dermal histogenesis disorders and alopecia.

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The review discussed the role of Wnt signaling in skin and hair follicle morphogenesis, highlighting its importance in cell proliferation and differentiation. Disruptions in Wnt signaling during prenatal and postnatal development were linked to degenerative and tumor diseases of the skin and hair. The study emphasized the significance of understanding epigenetic regulation in skin development, as prenatal disorders could manifest long after birth. It was noted that activation of the mother's immune system during early pregnancy led to transient alopecia in mouse offspring, suggesting a connection between epidermal and dermal histogenesis disorders and alopecia. The review underscored the need for further research into the rates and features of skin development across different body regions.

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