SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

    Tracy Tabib, Christina Morse, Ting Wang, Wei Chen, Robert Lafyatis
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    TLDR Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.
    The study by Tabib et al. from April 1, 2018, used single-cell RNA sequencing to identify two major fibroblast populations in human skin, characterized by distinct gene expressions SFRP2/DPP4 and FMO1/LSP1, and confirmed by immunofluorescent staining. These populations showed different morphologies and potential functional roles in the skin. Additionally, the study found further subpopulations within these groups and five minor fibroblast populations with unique gene expressions, suggesting specialized functions and progenitor potentials. The research, which examined 8,522 cells from six subjects, also noted that common fibroblast markers were not specific to fibroblasts and that type 1 collagen genes were the most consistent markers. The findings provide insights into the functional heterogeneity of dermal fibroblasts and their roles in skin biology.
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