Image

    Beyond Hair Preservation: Scalp Cooling as a Biopsychosocial Intervention in Patients Receiving Highly Alopecia-Inducing Chemotherapy

    March 2026
    Dörthe Schaffrin-Nabe, Anke Josten-Nabe, Adrian Heinze … R. Voigtmann
    Studysummary This study found that scalp cooling effectively prevented visible hair loss in over half of patients undergoing highly alopecia-inducing chemotherapy, yet cognitive appraisal of the treatment had a more significant impact on quality of life than the actual degree of hair retention.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on preprints.jmir.org →
    Discuss this study in the Community →

    Research cited in this study 19

    1. Prevention of Chemotherapy Drug-Mediated Human Hair Follicle Damage: Combined Use of Cooling with Antioxidant Suppresses Oxidative Stress and Prevents Matrix Keratinocyte Cytotoxicity Frontiers in Pharmacology · 2025
    2. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    3. Effect of N-Acetylcysteine on Hair Follicle Changes in Mouse Model of Cyclophosphamide-Induced Alopecia: Histological and Biochemical Study Histochemistry and cell biology · 2024
    4. Human Hair Keratin Responds to Oxidative Stress via Reactive Sulfur and Supersulfides Advances in Redox Research · 2024
    5. Hair Lipid Structure: Effect of Surfactants Cosmetics · 2023
    6. Mild Oxidative Stress Protects Against Chemotherapy-Induced Hair Loss Frontiers in Oncology · 2023
    7. A Systematic Review on the Lipid Composition of Human Hair International Journal of Dermatology · 2022
    8. Kartogenin Regulates Hair Growth and Hair Cycling Transition International Journal of Medical Sciences · 2022
    9. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    10. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019
    11. The Physical and Chemical Disruption of Human Hair After Bleaching – Studies by Transmission Electron Microscopy and Redox Proteomics International Journal of Cosmetic Science · 2018
    12. Melatonin Vitamin C-Based Nanovesicles for Treatment of Androgenic Alopecia: Design, Characterization and Clinical Appraisal European Journal of Pharmaceutical Sciences · 2018
    13. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    14. Cross-Section Trichometry: A Clinical Tool for Assessing the Progression and Treatment Response of Alopecia International journal of trichology · 2012
    15. Development of a Classification System for Extrinsic Hair Damage: Standard Grading of Electron Microscopic Findings of Damaged Hairs ˜The œAmerican journal of dermatopathology/American journal of dermatopathology · 2010
    16. Photoaggravation of Hair Aging International Journal of Trichology · 2009
    17. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    18. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    19. Prevention of Doxorubicin-Induced Alopecia by Scalp Hypothermia: Relation to Degree of Cooling The BMJ · 1982