Epidermal Differentiation: The Role of Proteases and Their Inhibitors

January 2004 in “ European Journal of Cell Biology ”

Patrick L.J.M. Zeeuwen

proteases protease inhibitors epidermal differentiation cornified cell envelope skin barrier function genetic mutations dermatological diseases protease-antiprotease system hair follicle differentiation SPINK5 Netherton syndrome cystatin M/E legumain cornification

Studysummary Balanced protease activity is crucial for healthy skin and hair development.

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research Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation

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research Matriptase/MT-SP1 Is Required for Postnatal Survival, Epidermal Barrier Function, Hair Follicle Development, and Thymic Homeostasis

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research Mice Lacking Desmocollin 1 Show Epidermal Fragility Accompanied by Barrier Defects and Abnormal Differentiation

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research Harlequin Ichthyosis (ICHQ): A Juvenile Lethal Mouse Mutation with Ichthyosiform Dermatitis

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research Expression of Morphogens During Human Follicle Development In Vivo and a Model for Studying Follicle Morphogenesis In Vitro

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research The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated (Cross-Linking) Protein

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