Randomized Controlled Trial of the Topical JAK Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia

    October 2025 in “ Journal of Investigative Dermatology ”
    Aubrey Martin, Neda Shokrian, Kristen J. Kelley … Maryanne M. Senna
    Studysummary In this study of women with frontal fibrosing alopecia, delgocitinib cream improved the molecular signature of lesions and demonstrated potential as a treatment, showing significant transcriptomic changes and some clinical improvements over 12 weeks compared to a cream vehicle.
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    Research cited in this study 7

    1. A Phase 2a Trial of Brepocitinib for Cicatricial Alopecia Journal of the American Academy of Dermatology · 2024
    2. Enhanced Insights Into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies Dermatology and Therapy · 2024
    3. Topical Tofacitinib for Patients with Lichen Planopilaris and/or Frontal Fibrosing Alopecia Journal of the American Academy of Dermatology · 2024
    4. Janus Kinase Inhibition for the Treatment of Refractory Frontal Fibrosing Alopecia: A Case Series and Review of the Literature JAAD Case Reports · 2023
    5. Janus Kinase Inhibitors for Alopecia Areata: A Narrative Review Indian journal of dermatology, venereology, and leprology · 2023
    6. A Phase 2a Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of the Oral Janus Kinase Inhibitors Ritlecitinib and Brepocitinib in Alopecia Areata: 24-Week Results Journal of the American Academy of Dermatology · 2021
    7. Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing British journal of dermatology/British journal of dermatology, Supplement · 2020