MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells

August 2022 in “ Viruses ”

Ruben Moreno, Darya Buehler, Paul F. Lambert

cutaneous squamous cell carcinoma Lgr5+ epithelial progenitor cells murine papillomavirus lineage tracing Lgr5-eGFP-IRES-CreERT2 Rosa26LSLtdTomato tdTomato+ cells squamous dysplasia Sox9 phospho-S6 cSCC Lgr5+ cells MmuPV1 Lgr5-eGFP Rosa26 tdTomato

Studysummary This study found that cutaneous squamous cell carcinomas in mice infected with murine papillomavirus preferentially arise from Lgr5+ progenitor cells, while squamous cell dysplasia does not.

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