Lgr5+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors

July 2016 in “ Oncotarget ”

Gerline C. van de Glind, Jacoba J. Out‐Luiting, Heggert Rebel, Cornelis P. Tensen, Frank R. de Gruijl

Lgr5+ stem cells epidermis hair follicles skin carcinogenesis tumor-initiating cells interfollicular epidermis CD34/K15+ quiescent bulge stem cells

Studysummary This study reports that actively proliferating Lgr5+ stem cells in hair follicles do not appear to drive tumor formation in experimental skin carcinogenesis.

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Research cited in this study

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research Progeny of Lgr5-Expressing Hair Follicle Stem Cell Contributes to Papillomavirus-Induced Tumor Development in Epidermis

52 citations , September 2012 in “Oncogene”

research Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis

338 citations , July 2009 in “Development”

This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice

141 citations , May 2007 in “Cancer Research”

This study found that CD34 is necessary for TPA-induced activation of hair follicle stem cells and tumor formation in mice, with CD34 knockout mice showing delayed and reduced tumor development compared to wild-types.

research The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells

207 citations , July 2006 in “Development”

This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.