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GlossaryCancer Stem Cells (tumor-initiating cells)

small subset of tumor cells that can self-renew and differentiate

Cancer Stem Cells (CSCs) are a small subset of cells within a tumor that possess the ability to self-renew and differentiate into various cell types found in the cancer. These cells are thought to be responsible for tumor growth, metastasis, and recurrence after treatment, making them a critical target for cancer therapies.

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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations, November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research Mouse Intestinal Krt15+ Crypt Cells Are Radio-Resistant and Tumor Initiating

33 citations, May 2018 in “Stem Cell Reports”

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

research Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution, And Tumor-Initiating Cells

37 citations, November 2017 in “Medical Sciences”

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

research Keratin-6 Driven ODC Expression in Hair Follicle Keratinocytes Enhances Stemness and Tumorigenesis by Negatively Regulating Notch

8 citations, August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

research Dormancy in the Stem Cell Niche

29 citations, March 2012 in “Stem Cell Research & Therapy”

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

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community U/joaopassos444 , HATS OFF brother !!

in Research/Science 127 upvotes 3 years ago

A new hair loss treatment theory beyond minoxidil and finasteride is proposed, causing mixed reactions in the community, with some members eager to explore and support it, while others call for more research and evidence.

community I don’t even care about my hair I just like taking drugs

in Satire 1 year ago

A user's experimentation with various hair loss treatments, including medications and topical applications; as well as their desire to experience unusual sensations through the use of drugs.

community Pyrilutamide 5 months results (before, after pics)

in Progress Pictures 196 upvotes 1 year ago

Tae147 has shared results of using pyrilutamide, a 5% concentration topical solution applied twice daily, in combination with minoxidil, to reduce scalp itchiness and hair shedding. Other users have shared their experiences with the treatment, as well as questions about its availability on the market.

community Did anybody not care at all about their hair until they started losing it?

in Chat 134 upvotes 1 month ago

People regret neglecting their hair until it started thinning, and they are now using treatments like finasteride, minoxidil, and microneedling. Some are considering stronger options like dutasteride due to mixed results.

community ‘Long term use of fin/dut may be associated with health risks including fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease and potential kidney disease.’

in Research/Science 22 upvotes 4 months ago

Long-term use of finasteride and dutasteride may be linked to health risks like fatty liver disease, insulin resistance, type 2 diabetes, dry eye disease, and potential kidney disease. Some users believe the risks are low and the medications are generally safe.

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