Platelet-Rich Plasma Injection and Lipofilling-Assisted Hair Transplantation on Residual Scalp Alopecia Post Aplasia Cutis Congenita Verticis

March 2025 in “ International Journal of Trichology ”

Ennio Montonati, Luca Codolini, Carolina Montonati, Maria Grazia Tarsitano, Riccardo Carbonaro, Giuseppe Sanese, Valerio Cervelli

platelet-rich plasma follicular unit transplantation fat grafting alopecia aplasia cutis congenita hair follicle scalp PRP hair transplant

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Hair Transplant →

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

Studysummary In this case report, researchers described a treatment for post-aplasia cutis congenita alopecia using follicular unit transplantation, platelet-rich plasma, and fat grafting, which significantly improved hair follicles, skin quality, and sensitivity in the affected scalp area.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study reports on a 16-year-old female with residual scalp alopecia from aplasia cutis congenita verticis (ACCV), treated using follicular unit transplantation (FUT), platelet-rich plasma (PRP) injections, and fat grafting. The combination therapy aimed to enhance hair follicle engraftment and improve skin quality in the scarred area. Over a 4-year follow-up, the patient experienced significant improvements in hair density and follicle survival rates, with 70% after the first transplant and 80% after the second. Additionally, skin characteristics such as thickness, vascularization, and sensitivity improved. The study suggests that combining regenerative techniques like PRP and fat grafting with FUT may be effective for treating cicatricial alopecia, indicating the need for further research.

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13 / 13 results

research Role of Hair Transplantation in Scarring Alopecia: To Do or Not to Do

3 citations , October 2021 in “Indian Journal of Plastic Surgery”

This review discusses cicatricial alopecias, highlighting the need for early diagnosis and aggressive treatment while evaluating the potential role of hair transplant in this condition, without reporting new clinical results.

research Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss

13 citations , August 2018 in “Facial Plastic Surgery Clinics of North America”

This review discusses the potential effectiveness of cell therapy for hair loss, highlighting promising early findings but emphasizing that more research is needed to explore specific therapies like autologous fat grafting and mesenchymal stem cells.

research Evaluating Platelet-Rich Plasma Therapy for Facial Aesthetics and Alopecia

31 citations , April 2018 in “Plastic and Reconstructive Surgery”

This review discusses the use of platelet-rich plasma for facial rejuvenation, acne scarring, and androgenic alopecia and reports positive outcomes but emphasizes the need for standardized preparation and application methods.

research Advances in Hair Restoration

17 citations , November 2017 in “Dermatologic Clinics”

This article discusses advancements in hair restoration, highlighting the use of robotics and follicular unit extraction along with adjuvant therapies like platelet-rich plasma, but presents no new clinical findings.

The Effect of Plasma Rich in Growth Factors Combined with Follicular Unit Extraction Surgery for the Treatment of Hair Loss: A Pilot Study

research The Effect of Plasma Rich in Growth Factors Combined with Follicular Unit Extraction Surgery for the Treatment of Hair Loss: A Pilot Study

12 citations , October 2017 in “Journal of Cosmetic Dermatology”

This study found that plasma rich in growth factors (PRGF) as an adjuvant to follicular unit extraction (FUE) surgery may enhance hair graft performance and reduce post-surgical inflammation and pain in hair loss patients.

Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

research Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

30 citations , June 2017 in “Current stem cell research & therapy”

This review discusses the potential of adipose-derived stem cells for hair regeneration and suggests that these cells and their conditioned media may offer a promising strategy for treating hair loss.

research Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

53 citations , June 2017 in “Skin appendage disorders”

This review suggests that platelet-rich plasma may be effective in increasing hair density in patients with androgenetic alopecia, but more research is needed to determine the best treatment protocol.

Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.

research Fat, Stem Cells, and Platelet-Rich Plasma

43 citations , June 2016 in “Clinics in Plastic Surgery”

This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.

research Hair Transplantation in Burn Scar Alopecia

8 citations , January 2015 in “Scars, burns & healing”

This review discusses surgical and non-surgical options for hair restoration in burn alopecia, highlighting follicular unit extraction and transplant as preferred methods but reports no new clinical findings.

Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth