Platelet-Rich Plasma Treatment for Endocrine-Induced Alopecia and Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Randomized, Controlled, Pilot Study

    July 2025 in “ Dermatologic Surgery
    Anthony Rossi, Alexander Pan, Christian Menzer, Leore Lavin, Saud Aleissa, Abdullah Aleisa, Hesham Alshaikh, George Dranitsaris, Stephen W. Dusza, Cindy Bravo, Mario E. Lacouture
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    TLDR PRP may increase hair density but doesn't improve quality of life in breast cancer survivors with hair loss.
    This study investigated the safety and efficacy of platelet-rich plasma (PRP) treatment for endocrine-induced alopecia (EIA) and persistent chemotherapy-induced alopecia (pCIA) in breast cancer survivors. Conducted as a single-center, randomized, controlled trial, it involved 15 EIA and 12 pCIA patients who received PRP injections on one side of their scalp monthly for 3 months. Results showed an improvement in the global assessment scale (GAS) from baseline to week 12, with hair density increasing on both treated and untreated sides. However, there was no significant difference between the sides, and quality of life did not improve. Adverse events included mild to moderate scalp pain, and no adverse cancer outcomes or tumor seeding were observed. The study suggests PRP may increase hair density, but results could be influenced by PRP diffusion in the split-scalp design.
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