The Effect of Platelet-Derived Growth Factor-AA (PDGFA) Conjugated with Low-Molecular-Weight Protamine (LMWP) on Hair Loss Improvement

December 2024 in “ Biochemical and Biophysical Research Communications ”

Seo Yeon Shin, Nu Ri Song, Dai Hyun Jung, Su Jung Kim, Kyung Mok Park

platelet-derived growth factor-AA PDGFA low-molecular-weight protamine LMWP 5α-reductase testosterone IGF-1 collagen synthesis transdermal delivery insulin-like growth factor 1

TLDR LMWP-PDGFA shows promise for improving hair health and treating hair loss with fewer side effects.

The study explores the effects of platelet-derived growth factor-AA (PDGFA) conjugated with low-molecular-weight protamine (LMWP) on hair loss, finding that LMWP-PDGFA enhances cell permeability and proliferation without cytotoxicity up to 100 ng/mL. It significantly inhibits testosterone-induced 5α-reductase activity, increases IGF-1 activity, and boosts collagen synthesis, which are vital for hair health. The results suggest that LMWP is a promising carrier for transdermal delivery of large molecules like PDGFA, offering a potential alternative to current hair loss treatments with fewer side effects. Further research is needed to elucidate the molecular mechanisms involved.

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