Subcutaneous Injection of Conditioned Medium from Photobiomodulation-Treated Adipose-Derived Stromal Cells Promotes Hair Growth in Mice

    In‐Su Park
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    TLDR Conditioned medium from treated cells boosts hair growth in mice.
    This study investigated the effects of subcutaneous injection of conditioned medium from photobiomodulation (PBM) irradiated adipose-derived stromal cells (ASCs) on hair growth in mice. Human ASCs were treated with a 660 nm light for 10 minutes daily over 10 days, and the conditioned medium (PBM-CM) was collected. Analysis showed increased secretion of growth factors such as VEGF, EGF, HGF, IGF, PDGF, and IGFBP in PBM-CM. The PBM-CM significantly enhanced hair growth in a hair loss model compared to non-irradiated ASC-CM or PBS, indicating that PBM is an effective biostimulator for hair regrowth and has potential for treating alopecia.
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