Genome-Wide Associations With Body and Fleece Weight in United States Sheep

    June 2025 in “ Genes ”
    Gabrielle M. Becker, Daniel Schaub, J. B. Taylor … Brenda M. Murdoch
    Studysummary This study conducted a genome-wide association analysis on 1,125 ewes and identified 24 SNPs associated with wool production traits, and highlighted potential candidate genes like <i>ADAR</i> and <i>TP53</i> for further research into the genetic mechanisms influencing wool growth in sheep.
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    Research cited in this study 14

    1. Genomic Characterization of Quality Wool Traits in Spanish Merino Sheep Genes · 2024
    2. Transcriptome Meta-Analysis Reveals Genetic Rules in Six Animal Breeds and Genes Associated with Wool Fineness Frontiers in Genetics · 2024
    3. Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits Biology · 2023
    4. Genomic Regions Associated With Wool, Growth, and Reproduction Traits in Uruguayan Merino Sheep Genes · 2023
    5. Identification of Genes Related to Hair Follicle Cycle Development in Inner Mongolia Cashmere Goat by WGCNA Frontiers in Veterinary Science · 2022
    6. Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep BMC genomics · 2022
    7. Identification of Key Genes and Signaling Pathways Related to Hetian Sheep Wool Density by RNA-Seq Technology PLOS ONE · 2022
    8. Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature Frontiers in cell and developmental biology · 2021
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    10. Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis Scientific Reports · 2021
    11. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    12. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner iScience · 2019
    13. Identification of Genes and Proteins Associated with Anagen Wool Growth Animal genetics · 2016
    14. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012