New Perspectives on Nutraceutical Insulin Sensitizing Agents in the Treatment of Psoriasis and Other Dermatological Diseases

August 2025 in “ International Journal of Molecular Sciences ”

Pietro Morrone, Francesca Caroppo, Alberto De Pedrini, Alessandro Colletti, Germano Baj

myo-inositol alpha-lipoic acid vitamin D vitamin C folic acid insulin resistance psoriasis acne hidradenitis suppurativa glycemic control oxidative stress inflammatory pathways polycystic ovary syndrome inositol ALA PCOS

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Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

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Folic acid →

Studysummary This narrative review suggests that nutraceutical insulin-sensitizing agents like myo-inositol, alpha-lipoic acid, and vitamins may improve glycemic control and reduce inflammation in insulin resistance-related skin disorders; however, more robust long-term trials are needed to confirm these findings and establish treatment regimens.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

14 / 14 results

Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study

research Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study

February 2025 in “Pharmaceuticals”

This study found that supplementing myo-inositol with microlipodispersed magnesium significantly improved acne and hirsutism in women with PCOS by reducing BMI, testosterone, and DHEAS levels, also enhancing quality of life without side effects, over 6 months.

research Inflammatory Loops in the Epithelial-Immune Microenvironment of the Skin and Skin Appendages in Chronic Inflammatory Diseases

3 citations , September 2023 in “Frontiers in immunology”

This study discusses the epithelial-immune microenvironment in chronic skin diseases, such as psoriasis and atopic dermatitis, and highlights current and future treatment strategies targeting inflammatory loops within these diseases.

Comparing the Efficacy of Myo-Inositol Plus Alpha-Lactalbumin Versus Myo-Inositol Alone on Reproductive and Metabolic Disturbances of Polycystic Ovary Syndrome

research Comparing the Efficacy of Myo-Inositol Plus Alpha-Lactalbumin Versus Myo-Inositol Alone on Reproductive and Metabolic Disturbances of Polycystic Ovary Syndrome

May 2023 in “Metabolites”

In this study, adding α-lactalbumin to myo-inositol treatment improved ovulation rates, menstrual cycle duration, and hyperandrogenism in women with PCOS more effectively than myo-inositol alone, suggesting potential benefits for those resistant to inositol treatment.

research The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

6 citations , December 2022 in “International Journal of Molecular Sciences”

This review explores the hormonal factors related to hidradenitis suppurativa, emphasizing insulin resistance and pro-inflammatory adipokines, but reports no new clinical findings and suggests further research is needed.

research Sex Hormone-Binding Globulin as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome

58 citations , November 2020 in “International Journal of Molecular Sciences”

This review discusses the relationship between SHBG, NAFLD, and PCOS and reports no new clinical results; the authors highlight low hepatic SHBG production as potentially significant in PCOS pathogenesis.

research What Causes Hidradenitis Suppurativa?—15 Years After

78 citations , October 2020 in “Experimental Dermatology”

This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.

Efficacy and Safety of Tracnil Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study

research Efficacy and Safety of Tracnil Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study

3 citations , March 2020 in “Dermatology Research and Practice”

In this study, 33 overweight women with normal hormone levels but showing PCOS symptoms experienced substantial reductions in acne lesions and improvements in hirsutism and menstrual irregularities after 8 weeks of Tracnil™ treatment, with minimal adverse reactions reported.

research Metabolic Syndrome and Skin Diseases

40 citations , November 2019 in “Frontiers in Endocrinology”

This review discusses the links between metabolic syndrome and various skin diseases, exploring shared mechanisms such as insulin resistance and inflammation, but reports no new clinical results.

Efficacy of Combination Therapy of Inositols, Antioxidants, and Vitamins in Obese and Non-Obese Women with Polycystic Ovary Syndrome: An Observational Study

research Efficacy of Combination Therapy of Inositols, Antioxidants, and Vitamins in Obese and Non-Obese Women with Polycystic Ovary Syndrome: An Observational Study

24 citations , July 2019 in “Journal of Obstetrics and Gynaecology”

This study found that a 12-week supplementation with a combination of insulin sensitizing agents, antioxidants, and vitamins significantly improved menstrual cyclicity, acne, and hirsutism in women with PCOS, with additional weight loss benefits in obese subjects.

research Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis

82 citations , May 2019 in “British Journal of Dermatology”

This review discusses various hormones and signaling pathways involved in sebaceous gland homeostasis and their potential impact on acne pathogenesis, but it reports no new experimental findings.

research Prolactin as a Candidate Sebotropic Hormone?

26 citations , March 2018 in “Experimental Dermatology”

This article argues that prolactin may have a role in sebaceous gland function and suggests it could be a potential target for treating skin conditions, but reports no new clinical findings.

research Insulin Resistance and Skin Diseases

71 citations , January 2015 in “The Scientific World Journal”

This review discusses the link between insulin resistance and skin conditions such as acanthosis nigricans and psoriasis, but provides no new clinical results.

research Vitamin D and the Skin: Physiology and Pathophysiology

158 citations , August 2011 in “Reviews in endocrine and metabolic disorders”

This review examines the functions of vitamin D and its receptor in skin and explores how these are regulated, reporting no new clinical results.

research Efficacy of Myo-Inositol in the Treatment of Cutaneous Disorders in Young Women with Polycystic Ovary Syndrome

64 citations , January 2009 in “Gynecological Endocrinology”

This study found that myo-inositol treatment reduced hirsutism and acne in women with PCOS by improving their metabolic profiles, including lower insulin and testosterone levels.