Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study

February 2025 in “ Pharmaceuticals ”

M Pezza, Valentina Carlomagno, Elena Sammarco, Antonino Trischitta, Carla Ceddia, Amalia Vitiello, Germano Baj, Valentina Citi, Alessandro Colletti

myo-inositol microlipodispersed magnesium androgen-dependent dermatological diseases acne hirsutism polycystic ovary syndrome testosterone free testosterone dehydroepiandrosterone sulfate Ferriman-Gallwey score LEVIGON PCOS DHEAS

TLDR Myo-inositol with magnesium effectively reduces acne and hirsutism in PCOS patients without side effects.

This retrospective study involving 200 patients with polycystic ovary syndrome (PCOS) examined the effects of a nutraceutical formulation, LEVIGON™, containing myo-inositol, microlipodispersed magnesium, and folic acid, on acne and hirsutism. Over 6 months, the supplementation significantly reduced body mass index (BMI), testosterone, free testosterone, and dehydroepiandrosterone sulfate (DHEAS) levels, improving the clinical picture of acne and hirsutism. Quality of life, assessed using the Cardiff Acne Disability Index (CADI) and Dermatology Life Quality Index (DLQI), improved significantly, and the Ferriman-Gallwey score for hirsutism showed notable improvement. The study concluded that myo-inositol with microlipodispersed magnesium is effective in reducing acne and hirsutism in PCOS patients without side effects, suggesting excellent compliance. Further long-term randomized clinical trials are recommended to confirm these findings.

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