Natural Potent Androgens: Lessons from Human Genetic Models

    Yuan‐Shan Zhu, Melissa D. Katz, Julianne Imperato‐McGinley
    Studysummary This article reviews the genetic mutations causing male pseudohermaphroditism from 17 beta-HSD-3 and 5 alpha-RD-2 deficiencies and reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

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    3. The Biochemical and Phenotypic Characterization of Females Homozygous for 5 Alpha-Reductase-2 Deficiency The Journal of Clinical Endocrinology & Metabolism · 1995
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    7. The Effects of Finasteride on Hair Growth, Hair Cycle Stage, and Serum Testosterone and Dihydrotestosterone in Adult Male and Female Stumptail Macaques The Journal of Clinical Endocrinology and Metabolism · 1994
    8. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    9. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993
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    11. Structure of Human Type II 5 Alpha-Reductase Gene Endocrinology · 1992
    12. Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque The Journal of Clinical Endocrinology and Metabolism · 1992
    13. C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 1990
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    15. Male Pseudohermaphroditism Due to 17β-Hydroxysteroid Dehydrogenase Deficiency: Studies on the Natural History of the Defect and Effect of Androgens on Gender Role Journal of Steroid Biochemistry · 1983