Natural Potent Androgens: Lessons from Human Genetic Models

April 1998 in “ Baillière s Clinical Endocrinology and Metabolism ”

Yuan‐Shan Zhu, Melissa D. Katz, Julianne Imperato‐McGinley

Studysummary This article reviews the genetic mutations causing male pseudohermaphroditism from 17 beta-HSD-3 and 5 alpha-RD-2 deficiencies and reports no new clinical findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Effect of Finasteride on Human Testicular Steroidogenesis

9 citations , September 1996 in “PubMed”

In this study, finasteride treatment for male pattern baldness improved hair loss and reduced prostate size, while increasing testosterone levels and altering steroid hormone ratios without affecting gonadotropin levels.

research 5 Alpha-Reductase-2 Gene Mutations in the Dominican Republic

53 citations , May 1996 in “The Journal of Clinical Endocrinology & Metabolism”

This study identified multiple mutations in the 5 alpha-reductase-2 gene among male pseudohermaphrodites in the Dominican Republic, suggesting they do not share a common ancestry.

research The Biochemical and Phenotypic Characterization of Females Homozygous for 5 Alpha-Reductase-2 Deficiency

54 citations , November 1995 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.

research Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism

70 citations , August 1995 in “Fertility and Sterility”

In this study, women with idiopathic hirsutism who took finasteride for 9 months experienced a significant reduction in hirsutism scores compared to those receiving a placebo, with minimal side effects.

research A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women

52 citations , January 1995 in “The Journal of Clinical Endocrinology and Metabolism”

This study observed that finasteride and spironolactone both led to a similar significant, but limited, improvement in hirsutism despite their differing effects on androgen levels.

research Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism

33 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that finasteride treatment significantly reduced hirsutism scores in women with idiopathic hirsutism over 6 months and was well tolerated.

The Effects of Finasteride on Hair Growth, Hair Cycle Stage, and Serum Testosterone and Dihydrotestosterone in Adult Male and Female Stumptail Macaques

research The Effects of Finasteride on Hair Growth, Hair Cycle Stage, and Serum Testosterone and Dihydrotestosterone in Adult Male and Female Stumptail Macaques

11 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride increases hair growth, prolongs hair cycle, and lowers dihydrotestosterone levels.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

70 citations , June 1993 in “Biochemistry”

This study found that the binding of finasteride to the enzyme 5a-reductase occurs at a slower rate than previously assumed, complicating the estimation of its real inhibitory constant.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.

research Structure of Human Type II 5 Alpha-Reductase Gene

124 citations , September 1992 in “Endocrinology”

This article discusses the structure of the human type II 5 alpha-reductase gene and reports no new experimental results.

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, the combination of finasteride and minoxidil significantly increased hair growth in balding male stumptail macaques compared to each drug alone.

C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

research C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

55 citations , March 1990 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that finasteride decreased plasma dihydrotestosterone levels and altered steroid metabolism, similar to the profile of male pseudohermaphrodites with inherited 5a-reductase deficiency.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

This study found significant species differences in the enzyme activity and inhibitor affinities of prostatic 5α-reductases from rats, dogs, and humans, with variable potencies for different 3-oxo-4-azasteroid inhibitors across species.

research Male Pseudohermaphroditism Due to 17β-Hydroxysteroid Dehydrogenase Deficiency: Studies on the Natural History of the Defect and Effect of Androgens on Gender Role

98 citations , July 1983 in “Journal of Steroid Biochemistry”

This study in the Arab population of Gaza described pseudohermaphroditism due to 17β-HSD deficiency, where individuals showed marked masculinization after puberty despite inadequate androgen proportions.