Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells

    March 2022 in “ Molecules ”
    Jaeyoon Kim, Jae Il Shin, Yun Shik Choi … Sang-Hwa Lee
    Studysummary This study found that adenosine promotes hair growth by stimulating the Wnt/β-catenin pathway in cultured human dermal papilla cells through activation of the adenosine receptor.
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    Research cited in this study 19

    1. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020
    2. Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells BMC complementary medicine and therapies · 2020
    3. Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells Biological & Pharmaceutical Bulletin · 2019
    4. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    5. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    6. Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development Frontiers in Cellular Neuroscience · 2019
    7. The Role of the VEGF, KGF, EGF, and TGF-β1 Growth Factors in the Pathogenesis of Telogen Effluvium in Women Biomedical and Pharmacology Journal · 2017
    8. Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    9. Topical Adenosine Increases the Proportion of Thick Hair in Caucasian Men With Androgenetic Alopecia Journal of Dermatology · 2015
    10. Topical Adenosine Increases Thick Hair Ratio in Japanese Men with Androgenetic Alopecia International Journal of Cosmetic Science · 2015
    11. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    12. Comparison of the Efficacy of Topical Minoxidil 5% and Adenosine 0.75% Solutions on Male Androgenetic Alopecia and Measuring Patient Satisfaction Rate PubMed · 2013
    13. Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles International Journal of Molecular Medicine · 2011
    14. Adenosine Increases Anagen Hair Growth And Thick Hairs In Japanese Women With Female Pattern Hair Loss: A Pilot, Double-Blind, Randomized, Placebo-Controlled Trial Journal of Dermatology · 2008
    15. L-Carnitine-L-Tartrate Promotes Human Hair Growth In Vitro Experimental Dermatology · 2007
    16. Indications That Topical L-Carnitine-L-Tartrate Promotes Human Hair Growth In Vivo Journal of dermatological science · 2007
    17. Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    18. Hair Cycle-Specific Expression of Versican in Human Hair Follicles Journal of Dermatological Science · 2005
    19. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001

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    1. Anti-Hair Loss Effect of Adenosine Is Exerted by cAMP Mediated Wnt/β-Catenin Pathway Stimulation via Modulation of GSK3β Activity in Cultured Human Dermal Papilla Cells Molecules · 2022