Metabolic Pathways of Eicosanoids: Derivatives of Arachidonic Acid and Their Significance in Skin

This review examines the metabolic pathways of eicosanoids, derivatives of arachidonic acid, and their importance in skin health and disease. Eicosanoids, produced by skin cells, are vital for maintaining skin homeostasis and regulating inflammation. Dysregulation of these molecules can lead to skin conditions like psoriasis and atopic dermatitis. The document highlights the roles of enzymes such as cyclooxygenases, lipoxygenases, and cytochrome P450 in eicosanoid metabolism, affecting processes like keratinocyte differentiation and hair follicle development. It suggests that targeting these pathways could offer therapeutic benefits, particularly through COX-2 inhibitors and other pharmacological interventions. The review calls for further research to better understand eicosanoid roles in skin diseases and to develop effective diagnostic and therapeutic strategies.