Melanocyte Dysfunctions: Future and Promise of Stem Cells

This review discusses the origin, characteristics, and therapeutic potential of melanocyte stem cells in skin pigmentation disorders and reports no clinical results.

This review highlights the diverse roles of melanocytes in pigmentation, immunity, and hearing among other functions, their involvement in disorders, and their emerging potential in regenerative medicine, including applications in disease modeling and therapy development using advanced technologies.

This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.

This paper provides a comprehensive review of melanocytes' roles in skin biology, focusing on their pigmentation and immune functions, and suggests potential research opportunities for preventing and treating skin disorders.

This review highlights the importance of using 3D scaffolds in vitro to support hair follicle regeneration, emphasizing how these structures help maintain cell function and mimic the natural environment, which is crucial for developing hair follicle organoids for transplantation.

This review discusses the role of various cells outside the hair follicle in regulating melanocyte stem cells and hair graying, but reports no new clinical results.

This study identified hair shaft progenitors in the matrix that regulate hair growth and pigmentation by creating a niche dependent on stem cell factor, implicating KROX20+ cells in these processes.

This review discusses recent research on melanocyte stem cells and explores the differences between mouse and human skin, but it reports no new clinical results.

This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.

This preliminary study observed that melanoblasts are preserved in the white hair follicles of segmental vitiligo lesions.