Melan-A Positive Cells Significantly Expressed in Immune-Targeted Follicles of Alopecia Areata

    August 2023 in “ Research Square (Research Square) ”
    Sherif Awad, Amal T. Abdel‐Rahman, Keroles Nageh, Manal Gabril
    Image of study
    TLDR Melanocytes may trigger the immune response in alopecia areata, affecting hair regrowth.
    The study on 16 alopecia areata (AA) patients found that Melan-A, a melanocytic marker, is significantly expressed in 50 out of 82 examined hair follicles, particularly in the lower follicular segment. This expression correlates with immune mononuclear infiltrates, suggesting that melanocytes may carry the antigenic epitope necessary to trigger the autoimmune response in AA. This could explain why only white hair regrows in some cases, supporting the theory that melanocytes play a crucial role in AA's pathogenesis and highlighting their potential as therapeutic targets.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community Great news recently for people with hairloss!

      in Research/Science  113 upvotes 11 months ago
      A potential treatment for alopecia involving a protein that calms hair follicles has shown promise in rats, but skepticism remains about its applicability to humans. Many users express doubt about the timeline for effective hair loss treatments, comparing it to past unfulfilled promises.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community I wish I were a man so bad. Life is cruel

      in Female  223 upvotes 2 weeks ago
      A woman with androgenetic alopecia uses Dutasteride and Bicalutamide but feels devastated due to increased sensitivity to DHT. She considers wigs, Minoxidil, and seeks advice on options like spironolactone, hair transplants, and therapy.

      community Brotzu lotion update

      in Update  90 upvotes 8 years ago
      A new hair loss lotion by Dr. Brotzu, expected to regrow up to 5 years of lost hair, is set to be released by Fidia Farmaceutici. It claims to work like minoxidil and finasteride without side effects, but skepticism exists due to its classification as a cosmetic product.

    Related Research

    5 / 5 results