Mediator 1 Ablation Induces Enamel-to-Hair Lineage Conversion Through Enhancer Dynamics

September 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Roman Thaler, Keigo Yoshizaki, Thai Nguyen, Satoshi Fukumoto, Pamela DenBesten, Daniel Bikle, Yuko Oda

Mediator 1 Med1 enhancer dynamics gene transcription tissue-specific lineage commitment dental epithelia hair growth primitive cellular aggregates super-enhancers enamel lineage transcription factors dental stem cells enhancer landscapes dental epithelial transcriptional program epidermis in vivo in vitro lineage reprogramming ectodermal regeneration

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary This study found that the deletion of Med1 in dental epithelia causes a shift from dental to hair tissue development, suggesting the importance of Med1 in maintaining tissue-specific lineage.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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