Mediator 1 Ablation Induces Enamel-to-Hair Lineage Conversion Through Enhancer Dynamics

    September 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Roman Thaler, Keigo Yoshizaki, Thai Nguyen, Satoshi Fukumoto, Pamela DenBesten, Daniel Bikle, Yuko Oda
    Image of study
    TLDR Removing Mediator 1 causes teeth cells to turn into hair cells.
    The study found that Mediator 1 (Med1), a key component of the Mediator complex that links enhancer activities to gene transcription, plays a crucial role in determining tissue-specific lineage commitment and progression of dental epithelia. When Med1 is deleted, it causes a shift in lineage, leading to hair growth in the dental environment. This unusual hair growth occurs via primitive cellular aggregates on incisors. Med1 establishes super-enhancers that control enamel lineage transcription factors in dental stem cells and their progenies. However, its deficiency reshapes the enhancer landscapes and causes a switch from the dental epithelial transcriptional program towards hair and epidermis on incisors in vivo, and in dental epithelial stem cells in vitro. The study suggests that Med1 safeguards lineage-specific enhancers and plays a central role in lineage reprogramming, providing new insights into ectodermal regeneration.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 9 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  100 upvotes 8 months ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Why I really believe the tension theory is the cause of MPB

      in Research/Science  70 upvotes 3 years ago
      The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

    Similar Research

    5 / 1000+ results