Low-Dose Oral Minoxidil in Lichen Planopilaris: Efficacy and Safety

    January 2025 in “ Dermatologic Therapy
    Mina Saber, Shaghayegh Dehghani, Farahnaz Fatemi Naeini, Fatemeh Mohaghegh
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    TLDR Low-dose oral minoxidil may help with symptoms and hair regrowth in lichen planopilaris without serious side effects.
    This study evaluated the efficacy and safety of adding low-dose oral minoxidil (OM) to methotrexate (MTX) treatment in 37 patients with lichen planopilaris (LPP), with 30 completing the study. Results showed that while both treatment groups improved in the Lichen Planopilaris Activity Index (LPPAI) and trichoscopic disease activity criteria, there was no significant difference in hair density and thickness between them. However, the combination group experienced significant improvements in symptoms like pain and burning sensation, and two patients showed hair regrowth in previously scarring areas. The study suggests that low-dose OM may offer additional benefits without serious side effects, although further research is needed to confirm these findings.
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