Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice

    April 2019 in “ Human & Experimental Toxicology ”
    Abdullah A. Alkahtane, Gadah Albasher, Nouf Alsultan … Mohamed M. Abdel-Daim
    Studysummary This study found that finasteride caused adverse effects on liver, kidney, and heart tissues in female mice, raising concerns about its potential use in females for treating androgenetic alopecia.
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    Research cited in this study 17

    1. Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway Drug Design Development and Therapy · 2017
    2. Connexin 43 Expression in the Testes During Postnatal Development of Finasteride-Treated Male Rat Offspring Archives of Medical Science · 2017
    3. A Serious Side Effect of a Potentially Widely Used Cosmetic Product Clinical and Experimental Dermatology · 2015
    4. Emerging Treatments in Alopecia Expert Opinion on Emerging Drugs · 2014
    5. Secondary Infertility Due to Use of Low-Dose Finasteride International Urology and Nephrology · 2012
    6. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    7. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    8. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    9. Finasteride-Associated Male Infertility Fertility and Sterility · 2010
    10. S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents British Journal of Dermatology · 2010
    11. Changes of Metabolic Profile in Men Treated for Androgenetic Alopecia with 1 mg Finasteride Endocrine Regulations · 2010
    12. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    13. Finasteride-Induced Myalgia and HyperCKemia Journal of Clinical Neuromuscular Disease · 2008
    14. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    15. Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study Archives of Andrology · 2007
    16. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    17. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992