Investigation of Follicular and Non-Follicular Pathways for Polyarginine and Oleic Acid-Modified Nanoparticles

November 2012 in “ Pharmaceutical research ”

Pinaki R. Desai, Priyanka Shah, Patrick Hayden, Mandip Singh

cell penetrating peptide CPP lipid nanoparticles oleic acid polymeric nanoparticles ibuprofen epidermis dermis hair follicles allergic contact dermatitis inflammatory skin diseases

Studysummary This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.

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research Triggering of Drug Release of Particles in Hair Follicles

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research Selective Follicular Targeting by Modification of the Particle Sizes

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This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Methods for Quantifying Intrafollicular Drug Delivery: A Critical Appraisal

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This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.

research Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam

74 citations , June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that hair follicles are a significant and efficient pathway for the absorption of topical minoxidil foam in humans, with faster blood detection when follicles are open.

research Targeting to the Hair Follicles: Current Status and Potential

142 citations , January 2010 in “Journal of dermatological science”

This review covers follicle-targeting drug delivery systems, exploring their potential for improving localized and systemic therapies, and highlights the need for further research into follicle penetration mechanisms.

research Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data

82 citations , May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

The study reported that combining the Follicular Closing Technique with the Franz diffusion cell is a valuable method for investigating follicular caffeine penetration in vitro, though kinetics differ from in vivo results.

research Follicular Transport Route: Research Progress and Future Perspectives

211 citations , February 2009 in “European journal of pharmaceutics and biopharmaceutics”

This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.

research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

182 citations , December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

This study demonstrated that hair follicles significantly expedite the absorption of caffeine through the skin compared to interfollicular pathways.

research Topical Delivery of Retinyl Ascorbate

8 citations , November 2007 in “Skin Pharmacology and Physiology”

In this study, skin stretching significantly increased the delivery of retinyl ascorbate into the dermis, while sealing hair follicles did not affect absorption through native skin.

research Innovative Liposomes as a Transfollicular Drug Delivery System: Penetration into Porcine Hair Follicles

161 citations , April 2006 in “Journal of Investigative Dermatology”

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research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations , April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that 40 nm nanoparticles can effectively penetrate into hair follicles and epidermal Langerhans cells in human skin samples, potentially enabling efficient transcutaneous vaccine delivery.

research Transfollicular Drug Delivery: Is It a Reality?

141 citations , November 2005 in “International journal of pharmaceutics”

This review examines the role of hair follicles and sebaceous glands in percutaneous drug delivery but does not report new clinical results; it calls for further exploration of follicle-targeting therapies.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.