Comprehensive Characterization of Keratin Extracted from Patients with Androgenetic Alopecia and Healthy Individuals Through Multimolecular Spectroscopy and Structural Analysis

    Le-Yi Zheng, Yi-Chen Zhu, Lei Gu, Ming-Ran Feng, Chang-Hua Xu
    TLDR Keratin in people with androgenetic alopecia shows specific changes that could help develop new treatments.
    This study provides a comprehensive characterization of keratin extracted from patients with androgenetic alopecia (AGA) compared to healthy individuals using a novel multimolecular spectroscopic analysis platform. The research involved 5 male patients with AGA and 5 healthy controls. Key findings include the identification of specific oxidation features linked to the instability of keratin's secondary structures, with notable changes in amino acids such as cysteine, glycine, and alanine. The study highlights potential biomarkers for assessing keratin alterations in AGA and offers insights into developing therapeutic strategies for keratin repair, providing a theoretical foundation for novel treatment approaches for AGA.
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