Kaempferol Stimulates Dermal Papilla Cells and Upregulates Wnt/β-Catenin Signaling Pathway for Androgenetic Alopecia Treatment

This study investigates the potential of kaempferol (Kae) as a treatment for androgenetic alopecia (AGA), a common form of hair loss. Kae was found to promote the proliferation and migration of dermal papilla cells (DPCs) and protect them from dihydrotestosterone (DHT)-induced damage. It activates the Wnt/β-catenin signaling pathway, crucial for hair growth. In vivo experiments on AGA mice showed that oral administration of Kae significantly enhanced hair regeneration, with effects comparable to finasteride, a standard AGA treatment. These findings suggest that Kae could be a promising alternative therapy for AGA, offering a safer option with fewer side effects than current treatments.