Enhanced Ex Vivo Skin Retention of Bicalutamide Using a Nano-in-Micro Composite: Drug-Loaded Lipid Vesicles in a Dissolving Microarray Patch

    April 2025 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Miquel Martínez‐Navarrete, Mafalda Correia, José Alejandro Bernabeu-Martínez … Antonio José Guillot
    Studysummary This study developed and tested Bicalutamide-loaded lipid vesicles in dissolving microarray patches for topical application, finding that they effectively deliver Bicalutamide through murine skin while maintaining a favorable safety profile, suggesting potential to improve treatments for androgenetic alopecia.
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    Research cited in this study 7

    1. Bicalutamide 25 Mg Associated With Minoxidil 1 Mg Versus Minoxidil 1 Mg for Female-Pattern Hair Loss: A Randomized Double-Blind Clinical Trial JAAD International · 2025
    2. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    3. Androgenetic Alopecia Among Hospital Staff: A Study of Prevalence, Types, and a Comparison with the General Population in a Secondary Hospital in China Clinical, Cosmetic and Investigational Dermatology · 2021
    4. Transdermal Permeation of Drugs in Various Animal Species Pharmaceutics · 2017
    5. Serendipity in Trichology International Journal of Trichology · 2011
    6. Treatment of Female Pattern Hair Loss With Oral Antiandrogens British Journal of Dermatology · 2005
    7. Antiandrogen Treatment of Polycystic Ovary Syndrome Endocrinology and Metabolism Clinics of North America · 1999