Sudden Improvement of Alopecia Universalis and Psoriatic Arthritis While Receiving Upadacitinib: A Case-Based Review

    October 2024 in “ Reumatismo ”
    Carlo Perricone, Roberto Dal Pozzolo, Giacomo Cafaro … Eugenia Bartoloni
    Studysummary This study reports a notable case of a patient with psoriatic arthritis and alopecia universalis who experienced significant improvement in both conditions after treatment with the JAK1 selective inhibitor upadacitinib, suggesting its potential efficacy for alopecia universalis, especially in cases involving inflammatory arthritis.
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    Research cited in this study 13

    1. Upadacitinib in Concurrent Crohn's Disease, Atopic Dermatitis, and Alopecia Areata: A Case Report Journal of the European Academy of Dermatology and Venereology · 2023
    2. Upadacitinib for Management of Recalcitrant Alopecia Areata: A Retrospective Case Series JAAD case reports · 2023
    3. Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata Over 52 Weeks in Phase III Trials American Journal of Clinical Dermatology · 2023
    4. Treatment of Alopecia Areata With the Janus Kinase Inhibitor Upadacitinib: A Retrospective Cohort Study Journal of the American Academy of Dermatology · 2023
    5. Successful Treatment of Concomitant Alopecia Universalis and Crohn's Disease with Upadacitinib: A Case Report SAGE Open Medical Case Reports · 2023
    6. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    7. JAK Inhibition in the Treatment of Alopecia Areata: A Promising New Dawn? Expert review of clinical pharmacology · 2019
    8. Treatment of Severe Alopecia Areata with Baricitinib JAAD Case Reports · 2019
    9. Janus Kinase Inhibitors: An Innovative Treatment for Alopecia Areata Journal of dermatology · 2019
    10. Health-Related Quality of Life Among Patients With Alopecia Areata: A Systematic Review Journal of The American Academy of Dermatology · 2016
    11. Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis British Journal of Dermatology · 2016
    12. The Autoimmune Basis of Alopecia Areata: A Comprehensive Review Autoimmunity reviews · 2014
    13. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014

    Related research 7

    1. Real-World Treatment Patterns Among Patients With Alopecia Areata in the USA: A Retrospective Claims Analysis Acta dermato-venereologica · 2023
    2. Alopecia Areata: Case Report and Review of Pathophysiology and Treatment with JAK Inhibitors Journal of autoimmunity · 2022
    3. The Usefulness and Wellbeing of Tofacitinib in the Treatment of Alopecia Areata Journal of Armed Forces Medical College, Bangladesh · 2022
    4. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    5. Transient Efficacy of Tofacitinib in Alopecia Areata Universalis Case Reports in Dermatology · 2016
    6. Alopecia Areata Universalis in a Dog Veterinary dermatology · 2015
    7. PUVA Therapy for Alopecia Areata 1981