Hypothesis: Wound-Induced TLR3 Activation Stimulates Endogenous Retinoic Acid Synthesis and Signalling During Regeneration

    March 2019 in “ Experimental dermatology ”
    Dong-Won Kim, Luis A. Garza
    Studysummary In this study involving adult mice, the researchers identified that double-stranded RNA-mediated activation of toll-like receptor 3 stimulates wound-induced hair neogenesis, potentially reflecting mechanisms used in facial rejuvenation treatments.
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    Research cited in this study 4

    1. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration Journal of Investigative Dermatology · 2017
    2. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    3. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007