Hormonal Profile and Anthropometric Indices as Determinants of Metabolic Risk in Polycystic Ovary Syndrome: A Prospective Observational Study

March 2026 in “ Cureus ”

Nigil Napolean, Shraddha Chaurasiya, Soumya Khanna, Shikha Sachan, Royana Singh, Jhumur Dey

polycystic ovary syndrome PCOS hormonal imbalances LH FSH AMH central obesity BMI WHR WHtR 2D:4D digit ratio prenatal androgen exposure fasting glucose lipid profiles endocrine factors body mass index waist-to-hip ratio waist-to-height ratio

Studysummary This study found that women with PCOS had significant hormonal imbalances, increased central obesity, and a lower 2D:4D digit ratio, suggesting prenatal androgen exposure may play a role in the condition's development.

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This study on polycystic ovary syndrome (PCOS) found that women with PCOS have significant hormonal imbalances, including elevated levels of LH, FSH, and AMH, and increased central obesity as indicated by higher BMI, WHR, and WHtR. The study also noted a lower 2D:4D digit ratio in women with PCOS, suggesting a link to prenatal androgen exposure. Despite these differences, fasting glucose and lipid profiles were similar between PCOS patients and healthy controls. The findings emphasize the need for early detection and comprehensive management of PCOS due to its complex interplay of developmental, metabolic, and endocrine factors.

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