Cardiovascular and Metabolic Risk Profiles Across Different Phenotypes of Polycystic Ovary Syndrome

This study investigated the cardiovascular and metabolic risk profiles of 240 women with polycystic ovary syndrome (PCOS) compared to 116 healthy controls. The women with PCOS were divided into four phenotypes based on the presence of hyperandrogenism, oligo/anovulation, and polycystic ovaries. The results showed that women with PCOS had significantly higher levels of triglycerides, fasting insulin, HOMA-IR, total testosterone, DHEAS, and LH/FSH ratio, and lower HDL cholesterol compared to controls. These findings highlight the increased cardiometabolic risks associated with PCOS, emphasizing the need for phenotype-specific management strategies.