Cardiovascular and Metabolic Risk Profiles Across Different Phenotypes of Polycystic Ovary Syndrome

November 2025 in “ Journal of Contemporary Medicine ”

Erson Aksu, Abdulaziz Gül

polycystic ovary syndrome PCOS hyperandrogenism oligo/anovulation polycystic ovaries triglycerides fasting insulin HOMA-IR total testosterone DHEAS LH/FSH ratio HDL cholesterol insulin resistance high testosterone low HDL

Studysummary This study observed that women with PCOS exhibited higher levels of triglycerides, fasting insulin, HOMA-IR, total testosterone, DHEAS, and LH/FSH ratio, and lower HDL cholesterol compared to healthy controls, with these markers varying across different PCOS phenotypes.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study investigated the cardiovascular and metabolic risk profiles of 240 women with polycystic ovary syndrome (PCOS) compared to 116 healthy controls. The women with PCOS were divided into four phenotypes based on the presence of hyperandrogenism, oligo/anovulation, and polycystic ovaries. The results showed that women with PCOS had significantly higher levels of triglycerides, fasting insulin, HOMA-IR, total testosterone, DHEAS, and LH/FSH ratio, and lower HDL cholesterol compared to controls. These findings highlight the increased cardiometabolic risks associated with PCOS, emphasizing the need for phenotype-specific management strategies.

View this study on dergipark.org.tr →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Women With PCOS Have a Heightened Risk of Cardiometabolic and Cardiovascular Diseases: Statement From the Experts Group on Inositol in Basic and Clinical Research and PCOS (EGOI-PCOS) and Italian Association of Hospital Cardiologists (ANMCO)

3 citations , September 2025 in “Frontiers in Cardiovascular Medicine”

This study reports that women with polycystic ovary syndrome, especially those with a hyperandrogenic pattern, are at a higher risk for cardiovascular disease compared to other PCOS patients, likely due to related metabolic comorbidities.

research Physiopathology of Polycystic Ovary Syndrome in Endocrinology, Metabolism, and Inflammation

70 citations , February 2025 in “Journal of Ovarian Research”

This review provides an analysis of the physiological and pathological aspects of polycystic ovary syndrome, emphasizing endocrine, metabolic, and inflammatory dimensions, but reports no new clinical results.

A Systematic Review of Models of Care for Polycystic Ovary Syndrome Highlights the Gap in the Literature, Especially in Developing Countries

research A Systematic Review of Models of Care for Polycystic Ovary Syndrome Highlights the Gap in the Literature, Especially in Developing Countries

2 citations , July 2023 in “Frontiers in Endocrinology”

This review identified and evaluated polycystic ovary syndrome models of care, finding that only three fully aligned with international guidelines and generally received positive feedback on satisfaction; just one showed an impact on patients' BMI.

Characterization of Metabolic Changes in the Phenotypes of Women with Polycystic Ovary Syndrome in a Large Mediterranean Population from Sicily

research Characterization of Metabolic Changes in the Phenotypes of Women with Polycystic Ovary Syndrome in a Large Mediterranean Population from Sicily

18 citations , July 2019 in “Clinical Endocrinology”

The researchers reported that among Mediterranean Sicilian women with PCOS, Phenotype B exhibited the most severe metabolic abnormalities, notably obesity and altered glucose metabolism, whereas Phenotype D showed no such issues.

Clinical and Endocrine Characteristics of the Main Polycystic Ovary Syndrome Phenotypes

Cardiovascular and Metabolic Risk Profiles Across Different Phenotypes of Polycystic Ovary Syndrome

Research cited in this study

research Women With PCOS Have a Heightened Risk of Cardiometabolic and Cardiovascular Diseases: Statement From the Experts Group on Inositol in Basic and Clinical Research and PCOS (EGOI-PCOS) and Italian Association of Hospital Cardiologists (ANMCO)

research Physiopathology of Polycystic Ovary Syndrome in Endocrinology, Metabolism, and Inflammation

research A Systematic Review of Models of Care for Polycystic Ovary Syndrome Highlights the Gap in the Literature, Especially in Developing Countries

research Characterization of Metabolic Changes in the Phenotypes of Women with Polycystic Ovary Syndrome in a Large Mediterranean Population from Sicily

research Clinical and Endocrine Characteristics of the Main Polycystic Ovary Syndrome Phenotypes

research Metabolic Features of the Reproductive Phenotypes of Polycystic Ovary Syndrome

research Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients