Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)

    January 2017 in “ Elsevier eBooks
    Jiro Kishimoto, Yosuke Nakazawa
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    TLDR The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.
    The 2017 document provides an extensive review of hair physiology, detailing the anatomy of the hair follicle, the hair growth cycle, and the role of various cells and growth factors in hair development and regeneration. It discusses the mechanisms behind hair growth and the challenges in creating cosmetic treatments targeting specific hair cycle phases. The document also examines factors influencing patterned hair loss, such as androgenetic alopecia, and the distinction between pharmaceuticals and cosmetics in hair growth promotion. Clinical tests on compounds like adenosine, t-Flavanone, cytopurine, and pentadecan showed promising results for improving hair loss. Additionally, it covers the effectiveness of ketoconazole, low-level laser therapy, and hair transplantation, while highlighting the potential of regenerative medicine and cell-based therapies, with a European clinical trial showing the safety of autologous human dermal sheath cup cells for hair loss treatment. The document underscores the social importance of hair and anticipates future treatments combining cosmetic products, clinical methods, and genetic manipulations.
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