Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)
January 2017
in “Elsevier eBooks”
TLDR The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.
The 2017 document provides an extensive review of hair physiology, detailing the anatomy of the hair follicle, the hair growth cycle, and the role of various cells and growth factors in hair development and regeneration. It discusses the mechanisms behind hair growth and the challenges in creating cosmetic treatments targeting specific hair cycle phases. The document also examines factors influencing patterned hair loss, such as androgenetic alopecia, and the distinction between pharmaceuticals and cosmetics in hair growth promotion. Clinical tests on compounds like adenosine, t-Flavanone, cytopurine, and pentadecan showed promising results for improving hair loss. Additionally, it covers the effectiveness of ketoconazole, low-level laser therapy, and hair transplantation, while highlighting the potential of regenerative medicine and cell-based therapies, with a European clinical trial showing the safety of autologous human dermal sheath cup cells for hair loss treatment. The document underscores the social importance of hair and anticipates future treatments combining cosmetic products, clinical methods, and genetic manipulations.
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Cited in this study
research Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia
Adenosine helps grow thicker hair in Japanese men with hair loss.
research Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system
Wnt1a helps keep cells that can grow hair effective for potential hair loss treatments.
research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
research Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men
Hair thickness matters more than density for baldness in Japanese men over 25.
research A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia
Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.
research Low‐level laser (light) therapy (LLLT) for treatment of hair loss
Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.
research Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline
More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.
research Narrow-band red LED light promotes mouse hair growth through paracrine growth factors from dermal papilla
Red LED light helps mouse hair grow by increasing growth factors from skin cells.
research Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men
Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.
research Role of genetics and sex steroid hormones in male androgenetic alopecia and female pattern hair loss: An update of what we now know
Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.
research Adenosine increases anagen hair growth and thick hairs in Japanese women with female pattern hair loss: A pilot, double-blind, randomized, placebo-controlled trial
Adenosine lotion improves hair growth and thickness in women with hair loss.
research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells
Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.
research Characteristic features of Japanese women's hair with aging and with progressing hair loss
Japanese women typically start experiencing hair loss after 40, with reduced hair density and thickness being the main factors.
research Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period
Great Burnet extract may prevent hair loss by extending the hair growth phase.
research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
research Expression Profiling and Cellular Localization of Genes Associated with the Hair Cycle Induced by Wax Depilation
research BMP signaling in the control of skin development and hair follicle growth
research Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis
Hair loss in balding individuals is linked to changes in specific hair growth-related genes.
research Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men
Ketoconazole shampoo with finasteride improves hair density in men with hair loss.
research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla
Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
research Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil
Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.
research Control of hair growth and follicle size by VEGF-mediated angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
research Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
Activating the Sonic hedgehog gene in mice can start the hair growth phase.
research Finasteride in the treatment of men with androgenetic alopecia
Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
research Long-term efficacy of topical minoxidil in male pattern baldness
Topical minoxidil effectively treats male pattern baldness and prevents hair loss.
research Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex
Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.
Related
research Hair Loss and Hirsutism Management
Low-level light therapy, possibly combined with other treatments, may become a leading hair loss treatment, while hirsutism often worsens with age and lacks preventive options.
research Hair loss (alopecia or baldness)
Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.
research Treatments of hereditary hair loss (alopecia)
Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.
research Hair Physiology (Hair Growth, Alopecia, Scalp Treatment, etc.)
The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.
research Disorders of Hair
The document's conclusion cannot be provided because the document is not readable or understandable.