Enhanced Skin Permeation of 5α-Reductase Inhibitors Entrapped into Surface-Modified Liquid Crystalline Nanoparticles

    August 2014 in “ Archives of Pharmacal Research ”
    Thiagarajan Madheswaran, Rengarajan Baskaran, Pasupathi Sundaramoorthy, Bong Kyu Yoo
    Studysummary This study found that surface-modified liquid crystalline nanoparticles significantly enhanced skin permeation of finasteride and dutasteride compared to unmodified nanoparticles, suggesting potential for improved treatment efficacy in androgenetic alopecia.
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    Research cited in this study 14

    1. Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants Aaps Pharmscitech · 2013
    2. The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride Journal of Dermatological Treatment · 2013
    3. New Investigational Drugs for Androgenetic Alopecia Expert Opinion on Investigational Drugs · 2013
    4. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    5. Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation Expert Opinion on Drug Safety · 2012
    6. Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments Dermatologic Clinics · 2012
    7. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    8. Combination Therapy With Finasteride and Low-Dose Dutasteride in the Treatment of Androgenetic Alopecia Australasian Journal of Dermatology · 2012
    9. A Randomized Double-Blind, Vehicle-Controlled Bilateral Comparison Study of the Efficacy and Safety of Finasteride 0.5% Solution in Combination with Intense Pulsed Light in the Treatment of Facial Hirsutism Journal of Cosmetic and Laser Therapy · 2012
    10. Finasteride and Sexual Side Effects Indian Dermatology Online Journal · 2012
    11. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    12. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    13. Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2009
    14. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000