TLDR Early diagnosis of GLPLS is crucial to prevent complications, but scarring alopecia is irreversible.
Grahams Little Piccardi Lausseur Syndrome (GLPLS) is a rare form of Lichen planopilaris, mainly affecting women aged 40-70, characterized by scarring alopecia on the scalp, non-scarring alopecia in the axilla and pubic regions, and follicular spinous papules on the trunk and extremities. Diagnosis is through clinical examination and histopathology, with the condition linked to defective cell-mediated immunity. Treatment options aim to halt progression and include retinoids, Tofacitinib, Hydroxychloroquine, corticosteroids, cyclosporine, anti-malarials, and PUVA therapy, but scarring alopecia is irreversible. Early diagnosis is crucial to prevent complications.
5 citations,
September 2021 in “Clinical case reports” GLPLS is a rare skin condition with specific hair loss and skin symptoms.
79 citations,
September 2018 in “Dermatologic therapy” Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.
160 citations,
March 2009 in “Seminars in Cutaneous Medicine and Surgery” New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.
22 citations,
June 2004 in “Journal of The European Academy of Dermatology and Venereology” A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.
March 2020 in “Clinical research in dermatology” Two unusual cases showed that Lichen Planopilaris can look like other skin conditions and need early treatment to protect hair.
23 citations,
April 2021 in “Journal of Clinical Medicine” Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.
3 citations,
October 2021 in “Journal of Cosmetic Dermatology” Trichoscopy helps tell apart Frontal Fibrosing Alopecia and Lichen planopilaris by showing different hair and scalp features.
November 2023 in “Journal of Cosmetic Dermatology” Injecting a person's own fat into their scalp may help regrow hair and improve hair thickness in different types of hair loss.
December 2020 in “Forum Dermatologicum” Intralesional triamcinolone acetonide can effectively limit the progression of GLPLS.
