Genetic and Environmental Factors That Control Merkel Cell Development and Survival

    July 2017 in “ D-Scholarship@Pitt (University of Pittsburgh) ”
    Gregory Logan-Graf
    Studysummary This study found that canonical Notch signaling inhibits Merkel cell specification during embryogenesis, while skin abrasions decrease Merkel cell number only in hairless mice.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 15

    1. Touch Receptors Undergo Rapid Remodeling in Healthy Skin Cell Reports · 2016
    2. Ectopic Atoh1 Expression Drives Merkel Cell Production in Embryonic, Postnatal, and Adult Epidermis Development · 2015
    3. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    4. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013
    5. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    6. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    7. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    8. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    9. Dynamic Plasticity of Axons Within a Cutaneous Milieu Journal of Neuroscience · 2010
    10. TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons ˜The œjournal of neuroscience/˜The œJournal of neuroscience · 2009
    11. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    12. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    13. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    14. Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice Journal of comparative neurology · 2002
    15. Dynamics of Merkel Cell Patterns in Developing Hair Follicles in the Dorsal Skin of Mice, Demonstrated by a Monoclonal Antibody to Mouse Keratin 8 Cells Tissues Organs · 1995

    Related research 4

    1. Tp63-Expressing Adult Epithelial Stem Cells Cross Lineage Boundaries Revealing Latent Hairy Skin Competence Nature Communications · 2020
    2. SOX2 in the Skin: Roles in Biology and Pathology Elsevier eBooks · 2015
    3. The Roles of Lrig1- and Lgr6-Positive Stem Cells in Skin and Functions of Their Molecular Markers eScholarship (California Digital Library) · 2014
    4. More Than One Way to Skin Genes & Development · 2008