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research Genetic and Environmental Factors that Control Merkel Cell Development and Survival

July 2017 in “D-Scholarship@Pitt (University of Pittsburgh)”

This study found that canonical Notch signaling inhibits Merkel cell specification during embryogenesis, while skin abrasions decrease Merkel cell number only in hairless mice.

ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research eLife assessment: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.

research Diversification and Specialization of Touch Receptors in Skin

81 citations , June 2014 in “Cold Spring Harbor perspectives in medicine”

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

Joint Public Review: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research Joint Public Review: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

This study found that the transcription factor Meis2 is crucial for the maturation and innervation of sensory neurons responsible for light touch in mice, with its absence leading to reduced touch sensitivity.

Author Response: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research Author Response: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

This study found that the transcription factor Meis2 regulates the maturation and innervation of sensory neurons in mice, affecting their response to light touch.

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community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

community Has anyone done research on Absci's AI‑driven antibody platform? Seeking your thoughts!

4 upvotes 1 year ago

A user is interested in Absci's AI-driven antibody platform, ABS-201, for treating androgenetic alopecia, which shows promising preclinical results and potential for hair regrowth and pigmentation restoration. However, concerns are raised about the drug's development timeline and its advantages compared to existing treatments.

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research Genetic and Environmental Factors that Control Merkel Cell Development and Survival

research eLife assessment: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

research Diversification and Specialization of Touch Receptors in Skin

research Joint Public Review: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

research Author Response: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

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community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

community Has anyone done research on Absci's AI‑driven antibody platform? Seeking your thoughts!

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