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    Autophagy Controls the Protein Composition of Hair Shafts

    July 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Supawadee Sukseree, Noreen Karim, Karin Jaeger … Leopold Eckhart
    Studysummary This study found that blocking autophagy in Atg7-deficient mouse hair keratinocytes altered the molecular composition of hair shafts by increasing the abundance of proteins involved in protein turnover while keratins remained unchanged, highlighting autophagy's role in reducing non-cytoskeletal protein concentrations in hair.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. Age-Related Changes in Hair Shaft Protein Profiling and Genetically Variant Peptides Forensic Science International Genetics · 2020
    2. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    3. Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function Experimental dermatology · 2018
    4. Development of Hair Fibers Advances in experimental medicine and biology · 2018
    5. The Walking Dead: Sequential Nuclear and Organelle Destruction During Hair Development British Journal of Dermatology · 2017
    6. Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair Journal of Investigative Dermatology · 2009