Association of Oxidative Stress in Mild Patchy Alopecia Areata: A Case-Control Study

October 2023 in “ Research Square (Research Square) ”

Sümeyye Altıntaş Kakşi, Gözde Ülfer, Alkım Ünal Çakıter, Tunç Özen, Türkan Yiğitbaşı, Mustafa Özdemır

alopecia areata oxidative stress total oxidant state total antioxidant state oxidative stress index ischemia-associated albumin antioxidant treatment AA TOS TAS OSI IMA

Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

Studysummary In this study, researchers found that patients with new-onset mild alopecia areata had higher levels of oxidative stress markers and reduced antioxidant levels compared to healthy individuals, suggesting that oxidative stress might play a role in the condition.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research The Role of Ischemia-Modified Albumin and Ischemia-Modified Albumin to Albumin Ratios in Patients with Alopecia Areata

3 citations , January 2023 in “Dermatology Practical & Conceptual”

In this study, the researchers reported that ischemia-modified albumin and IMA/albumin levels may not effectively predict disease severity in patients with alopecia areata.

research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches

15 citations , January 2023 in “Antioxidants”

This review discusses oxidative stress in alopecia areata pathogenesis and potential treatment strategies, reporting no new clinical results but suggesting biomarkers for oxidative stress and discussing JAK inhibitors as promising options.

research Ischemia-Modified Albumin: A Potential New Marker of Oxidative Stress in Dermatological Diseases

6 citations , May 2022 in “Medicina-lithuania”

This review discusses ischemia-modified albumin as a potential new marker of oxidative stress in dermatological diseases but reports no new clinical findings.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options

56 citations , January 2021 in “Clinical and Experimental Medicine”

This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.

research Ischemia-Modified Albumin as a Possible Marker of Oxidative Stress in Patients with Telogen Effluvium

8 citations , May 2020 in “Anais Brasileiros de Dermatologia”

This study found that serum ischemia-modified albumin levels were significantly higher in patients with telogen effluvium compared to healthy controls, suggesting a potential role of oxidative stress in the condition's pathogenesis.

research Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

16 citations , December 2018 in “Skin pharmacology and physiology”

This study found that in people with alopecia areata, oxidative stress indicators were higher and specific enzyme activities were lower compared to healthy controls, suggesting oxidative stress's significant role in disease pathogenesis.

research Review of Treatment for Alopecia Totalis and Alopecia Universalis

44 citations , April 2017 in “International Journal of Dermatology”

This study reviewed treatment options for alopecia areata totalis and universalis, finding no completely effective therapy. Promising treatments with quality data include diphenylcyclopropenone, squaric acid dibutylester, and photodynamic therapy, but larger, high-quality trials are needed.

Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata

research Preferential Recognition of Hydroxyl Radical-Modified Superoxide Dismutase by Circulating Autoantibodies in Patients with Alopecia Areata

12 citations , January 2014 in “Annals of Dermatology”

This study found an association between hydroxyl radical-modified SOD and alopecia areata, suggesting these modifications may lead to antibody induction in the condition.

research Oxidative Stress in Alopecia Areata: A Case-Control Study

62 citations , July 2013 in “American Journal of Clinical Dermatology”

This study found that alopecia areata patients had higher oxidative stress and lipid peroxidation levels than healthy controls, suggesting potential involvement in the disease's pathogenesis.

research Alopecia Areata Update

85 citations , October 2012 in “Dermatologic Clinics”

This article reviews recent updates on alopecia areata, focusing on its causes, clinical presentation, and treatment options, and provides treatment plans by patient age and disease extent, but reports no new clinical results.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia

55 citations , January 2000 in “Cell biochemistry and function”

This study observed that patients with alopecia had increased lipid peroxidation and decreased antioxidants, including lower beta-carotene, GSH levels, and GSH-Px activity, compared to healthy controls.