Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation

    February 2019 in “ BioMed Research International ”
    Fu‐Ming Tsai, Chao-Hsu Li, Lu‐Kai Wang … Chun‐Hua Wang
    Studysummary In this study, ebastine significantly increased the proliferation of human follicle dermal papilla cells and may contribute to hair regrowth by activating the ERK signaling pathway.
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    Research cited in this study 8

    1. Epidemiology and Burden of Alopecia Areata: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2015
    2. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata Clinical and Developmental Immunology · 2013
    3. Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures Genomics · 2010
    4. Experimental Evaluation of Ebastine, a Second-Generation Antihistamine, as a Supportive Medication for Alopecia Areata Journal of Dermatological Science · 2010
    5. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    6. Study on Histamine Related Enzyme Activities During Murine Hair Cycle EXPERIMENTAL ANIMALS · 1997
    7. Treatment of Female Androgenetic Alopecia With Cimetidine International Journal of Dermatology · 1987
    8. Reversal of Male-Pattern Baldness, Hypertrichosis, and Accelerated Hair and Nail Growth in Patients Receiving Benoxaprofen BMJ · 1982

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    3. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    4. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994