Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation

February 2019 in “ BioMed Research International ”

Fu‐Ming Tsai, Chao-Hsu Li, Lu‐Kai Wang, Mao‐Liang Chen, Ming‐Cheng Lee, Yi‐Ying Lin, Chun‐Hua Wang

ebastine human follicle dermal papilla cell HFDPC extracellular signal-regulated kinase ERK phospho-AKT phospho-p44/42 ERK cell-cycle regulatory proteins antiapoptotic proteins histamine H1 receptor antagonist ERK signaling pathway

Studysummary In this study, ebastine significantly increased the proliferation of human follicle dermal papilla cells and may contribute to hair regrowth by activating the ERK signaling pathway.

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