4 citations
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February 2019 in “BioMed Research International” Ebastine, a second-generation histamine H1 receptor antagonist, was studied for its effects on human follicle dermal papilla cell (HFDPC) proliferation, which is relevant to hair regrowth. The study used WST-1 and bromodeoxyuridine incorporation assays to demonstrate that ebastine significantly increased HFDPC proliferation. This increase was associated with elevated expression of cell-cycle regulatory and antiapoptotic proteins, as well as increased levels of phospho-AKT and phospho-p44/42 ERK. The proliferation effect was completely reversed by blocking ERK kinase, suggesting that ebastine may promote hair regrowth through the ERK signaling pathway.
5 citations
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September 2022 in “Antioxidants” A substance from Caulerpa racemosa seaweed may protect against skin damage caused by air pollution by reducing oxidative stress and cell death.
36 citations
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March 2009 in “Molecular Carcinogenesis” Disrupting Bcl-xL in mice reduces skin cancer risk.
23 citations
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January 2002 in “Journal of Cutaneous Medicine and Surgery” Finasteride helps hair growth by decreasing cell death in hair follicles.
21 citations
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January 2002 in “Journal of Cutaneous Medicine and Surgery” Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.