Study on Histamine Related Enzyme Activities During Murine Hair Cycle

The study on C3H mice examined histamine-related enzyme activities during the hair cycle, particularly focusing on histidine decarboxylase's role in hair regrowth. It was found that after depilation, histidine decarboxylase activity significantly increased and then normalized within two weeks, suggesting its involvement in initiating the anagen phase of hair growth. Additionally, histamine content rose post-depilation, indicating a potential link between histamine synthesis and hair regrowth. However, histamine N-methyltransferase activity did not correlate with hair regrowth. These findings suggested that histamine and its synthesizing enzyme might play a crucial role in the early stages of hair regrowth.