26 citations
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August 2019 in “Stem Cell Research & Therapy” PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.
4 citations
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February 2019 in “BioMed Research International” Ebastine, a second-generation histamine H1 receptor antagonist, was studied for its effects on human follicle dermal papilla cell (HFDPC) proliferation, which is relevant to hair regrowth. The study used WST-1 and bromodeoxyuridine incorporation assays to demonstrate that ebastine significantly increased HFDPC proliferation. This increase was associated with elevated expression of cell-cycle regulatory and antiapoptotic proteins, as well as increased levels of phospho-AKT and phospho-p44/42 ERK. The proliferation effect was completely reversed by blocking ERK kinase, suggesting that ebastine may promote hair regrowth through the ERK signaling pathway.
106 citations
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October 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
28 citations
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May 2018 in “Scientific reports” Exercise improves insulin sensitivity and hormone regulation in PCOS rats.
11 citations
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September 2019 in “Dermatologic Surgery” A substance called Vascular Endothelial Growth Factor can protect certain hair follicle stem cells from damage caused by androgens, suggesting a new possible treatment for hair loss.