4 citations
,
February 2019 in “BioMed Research International” Ebastine, a second-generation histamine H1 receptor antagonist, was studied for its effects on human follicle dermal papilla cell (HFDPC) proliferation, which is relevant to hair regrowth. The study used WST-1 and bromodeoxyuridine incorporation assays to demonstrate that ebastine significantly increased HFDPC proliferation. This increase was associated with elevated expression of cell-cycle regulatory and antiapoptotic proteins, as well as increased levels of phospho-AKT and phospho-p44/42 ERK. The proliferation effect was completely reversed by blocking ERK kinase, suggesting that ebastine may promote hair regrowth through the ERK signaling pathway.
1 citations
,
January 2024 in “NPJ breast cancer” Experts agree on how to manage sugar levels and skin reactions in patients taking the cancer drug alpelisib.
7 citations
,
April 2021 in “Dermatology and Therapy” H-1 antihistamines may help with various skin conditions, but more research is needed to confirm their effectiveness.
2 citations
,
October 2023 in “Science advances” Touching hair can activate nearby nerve cells through signals from the hair's outer layer.
24 citations
,
December 2009 in “Future Medicinal Chemistry” Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.