Effects of Skin Environmental Changes by Steam Towel, Ethanol, L-Menthol and Carpronium on the Drug Behavior in Minoxidil Nanoparticles-Applied Mice

    January 2022 in “ Yakugaku zasshi ”
    Ryoka Goto, Yoshihiro Oaku, Fuka Sasaki, Chika Kubota, Saori Deguchi, Reita Kadowaki, Akinari Abe, Tohru Nagahama, Noriaki Nagai
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    TLDR Using a steam towel, l-menthol, and carpronium before applying minoxidil nanoparticles can increase its absorption and potentially improve hair growth.
    The researchers investigated how changes in the skin environment affected the absorption of minoxidil nanoparticles (MXD-NPs) in mice. They found that pre-treatment with a steam towel and l-menthol increased the levels of minoxidil in the hair bulb, while pre-treatment with ethanol increased the levels in the skin tissue. Additionally, pre-treatment with commercially available carpronium (CA-carpronium) significantly increased the levels of minoxidil in the hair bulb, bulb, and skin tissue. These findings suggest that changes in the skin environment can enhance the absorption of MXD-NPs and potentially improve the therapeutic efficiency of minoxidil for hair growth without side effects.
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